Saturday, August 31, 2019

Women Are Still Treated as Second Class Citizens

Plan: For |Against | |Same jobs, paid less |Able to do any jobs, just not cut-throat | |‘Traditional’ |Can do more jobs than before S&S | |Higher jobs dominated by men |Hard for men to be accepted in women’s jobs too | |‘Old boy network’ |Dangers for women | |‘Glass ceiling’ |Religion | |Just want to be taken seriously |Women saved first on crashes etc | |Exam results |Stay-at home dads | |Not stay-at-home-dads as they can earn more money | | The ‘Old boy Network’? Wrong Frequency For Women. Ladies and Gentlemen; I believe that it is time for change. Change not only to the ‘pecking order’ but to opinions as a whole. Read this with an open mind, as I believe that together in unity we can make women’s voices heard over the noises of vacuum cleaners and screaming children. Is there any reason for women to still be treated as second-class citizens here in the UK? Do their fingers really have the magic touch for housework and not hard work? Of course not! Everyone knows that women are perceived in this way because of tradition. A tradition that we cannot will not and should not be part of. Just because women used to have to stay at home and look after children, or men did all of the ‘dangerous jobs’ why should that still be the case? Women have undoubtedly proven themselves just as capable, if not more, than men in most jobs, so why is it still so hard for them to break through that ‘glass ceiling’? Many women will have been in the position where a male colleague earns more than them for doing the exact same job. This is unfair treatment and should not be condoned. A friend of mine called Annabelle is an excellent banker, the best out her level of the company, yet she has been repeatedly rejected from a higher positioned job in the company. Each of these times the positions have been given to a male. A coincidence? I think not. She was more highly qualified than these men, and had worked for the company for longer, so why was she overlooked? Has The ‘Old boy network’ been on the rampage again? Is it because women occupy only 1 in 20 of the ‘top jobs’? Will it really come to her loosing her femininity to get the job she really deserves? Women just want to be taken seriously and to get the respect they deserve, yet is seems that most of the time to reach their goals they have to loose friends, and dress or act like men. Why is it harder for women to gain the respect of men than the other way around? In a recent survey only 3 out of 50 women said that they would be comfortable being in control of an office or group of men, yet 42 out of 50 men said they would be comfortable being in control of women. Others will argue that women are the ones that are too scared to break out of traditional placements. There are no jobs that only men are allowed to do, it is just that many women won’t go into these jobs, as the dangers are too high, or the hours will not let them see their families often enough. Women are not ‘cut-throat’ enough. They do not want to trample on people on the way to the top, as they do not have that sort of mentality. Most men will go to any extremes to secure their ‘dream job’. Women can do many more jobs than even 50 years ago. Their rights have improved tremendously, and now cannot be discriminated against. It is extremely hard for men to be accepted into predominantly woman-dominated jobs. It is not something against women, just something that is to be expected if any sex is going into the ‘other sex’s territory’. For example, male nurses are often abused or made fun of because they are not doctors, and women doctors find it hard to be taken seriously by the male doctors. The dangers of some jobs for many women outweigh anything else. Men have the physiques to estrain, resist and persist against tough weather, or heavy objects, ‘it is a biological fact that women are generally weaker than men. ’ In many of the religions now observed in the UK the women are treated worse than the men, yet this is their choice. If they did not agree with it, the wome n could leave the religion, and be treated as equals in the multi-religion society that is the United Kingdom. There are 20% more ‘stay-at-home-dads’ than 30 years ago. This shows that the women are free to work, and the men can do all of the ‘traditional’ female jobs. Many women are not taken on at the higher jobs because of the worry of maternity leave. The companies employing them must think of the future and the inevitability that at some point most 30-year-old women will want children. Another main point is that women are saved first, along with children, on sinking ships, or crashes. This means that their lives are put above men’s. The fact that men are not generally the parents who stay at home backs up the argument that men will be more likely to be paid more, whether it is due to a higher position, or a wider range of jobs open to them. Girls have been out–shining boys in the public exams for years now, which shows that they are not only qualified to do the same jobs, but in many cases more qualified. If you think of any type of job that both men and women do, and think of the ‘high-flyers’ within those jobs you will certainly think of a man. This needs to change. Women will inevitably keep fighting for their rights; ‘we will not tire, we will not falter and we will not fail’ when it comes to getting what we deserve. Dr. James Macaroni of Oxford University told us that women get more stressed at work due to the pressure and strain of having to constantly work at the same level, whereas men get breaks within their stress when they get promoted. Do we really want to have women constantly put below men? Should women always stay traditional? So, fellow readers, I ask, why not change the pecking order today? Why wait until it is too late?

Friday, August 30, 2019

Importance of Carnival in Aphra Behn’s The Rover Essay

â€Å"Masquerading! A lewd custom to debauch our youth. There’s something more in this than I imagine.† – Don Pedro Aphra Behn, the first female playwright to earn a living through her writing, was also one of the wittiest and entertaining as evidenced through her most well known play, The Rover. Set in 17th century Italy while under the colonial reign of Spain, a large cast of characters becomes embroiled in scenes of infidelity, seduction, misrepresentation, and elaborate swordplay, which create tension and confusion in addition to many comedic episodes. The setting is Carnival time in Venice, which is important to the plot for several reasons: the wearing of masks (as was customary) allows a freedom from normal constraints, there is often in the play a mistake made in identities, circumstances can (and do) occur which could never otherwise happen, it allows for a fast pace to be maintained which keeps the spectators involved, and ultimately, â€Å"confusion captures the spirit of the carnival† (1). During carnival times class barriers came down with the rich mingling with the poor. The tradition of wearing masks at carnival time became necessary in order to protect the identities of the rich (2). This also gave opportunities to act out in a manner far removed from their habitual one. By having her female characters hidden behind masks, Behn is able to remove them from their traditional roles as women and give them empowerment. In effect, they can assume new personalities and remove their inhibitions or the otherwise usual yokes that have been cast on them by a male-dominated society. Hellena is the perfect example of one throwing off inhibitions and revealing her inner self behind the guise of a mask. Slated for the convent in an effort by her father to consolidate the family finances, she decides that this carnival will be the time she finds a man – and she sets her sights on one as daring and quick-witted as herself. She is able to track him in different disguises and at one point sets out to â€Å"vex† him for his keeping with Angellica. She shows herself to be a strong, independent-thinking woman in an age when women had few personal rights. The carnival setting is the  vehicle that gives her the freedom to behave in the manner she does. The carnival setting is also the cause of mistaken identities. Because of this confusion Behn is able to further the comedic and suspense elements. For example, Don Pedro is denied his opportunity with the lovely Angellica when his friend (and his intended brother-in-law) Don Antonio pays his offering to be with her. Don Pedro is further incensed by the fact that this is a slight against his sister, Florinda, which ultimately leads to the setting of a time and place for a duel. Of course, Don Antonio believes he is confronting Belvile from his verbal exchange with Don Pedro. Ironically, when Belvile comes to the aid of Don Antonio later, he is charged with actually doing the crime of injuring him. Unwittingly, Don Antonio presses Belvile into fighting for him against Don Pedro for the honor of Florinda, Belvile’s love! This is one of many instances when the characters end up in entertaining situations due to mistaken identity. The mistakes made by the characters often misidentifying each other has an added effect of the audience having to pay especially close attention themselves to how the plot develops. Since all of the action occurs during Carnival (especially Venetian), the audience naturally expects some kind of confusion and mayhem to occur. This chaotic environment keeps the pace quickened making the carnival setting a natural choice for a swift paced play. Traditionally, carnivals of this kind â€Å"would take place in the various Venetian piazzas and would involve meals of imported delicacies, dancing and entertainment by jugglers, acrobats, etc. as well a feats of strength or daring, performed by young men, and usually resulting in being plunged into the freezing waters of the canal.†(2). With the goings-on throughout the city during Carnival, the play (as the spectators expect) would naturally exhibit the same impulsive atmosphere of gaiety and rapidity of movement that occur during carnivals. The play is also making a forward statement for its time and can because of the particular nature of the carnival. Through Hellena, Behn is speaking for women’s equality. Hellena while disguised is as courageous and outspoken as any man of the period. She is able to act as men do – choosing a mate as one  would livestock. Another unspoken assertion Behn makes is of the treatment of women who were not privileged. Repeated attempts at raping Florinda because the men thought she was of a lower station don’t put men in a good light. The attitudes of these men are that this is accepted practice and tolerated in 17th century society. Undeniably, it would seem as if they saw it as their right. Finally, while most men would look at Willmore’s cavalier attitude and behavior with what one might call reverence (who wouldn’t want to be a swashbuckler?), his lying, deceitfulness, and womanizing ways are not qualities that cause one to shine. These things along with the women’s sexual audaciousness would cause this play to be denigrated in the next era. In conclusion, Behn’s choice to place the action of the play in Venice during a carnival was appropriate to the theme. Indeed, one could argue that without the carnival as a backdrop, Behn could not have as effectively pulled off the character’s relationships and the myriad encounters nearly as well. The characters actions speak as much if not more than their words do and the speed of the play is determined by these actions. This could only have been achieved by the confusion and spontaneity inherent in the nature of carnivals. Thus, the importance of Carnival in Aphra Behn’s The Rover was paramount to the success of the play.

Thursday, August 29, 2019

Auditing Assignment Example | Topics and Well Written Essays - 1000 words

Auditing - Assignment Example The procedures involved in the investigation include, going through the reports by preceding editors, obtaining information from the management whether any of the officers has been convicted with crime. Carrying out the fact-finding mission of the preceding auditors on management’s integrity, disagreements or any other additional information on why the firm should decline the audit. Finally, there is discussion the potential client with the attorneys and bankers of the entity. The client continuance and acceptance forms facilitate the continuing and prospective client’s investigations. The forms undergo updating and renewal yearly to keep evaluating engagement and association with the client. The investigation of both the new and renewal clients is important for it enables the firm to establish the quality of the client they serve as well as if and they meet the standards. At the same time, the forms are essential in the bid to avoid omissions in the whole process of investigation. On accepting the client or renewing the engagement, the client personnel’s quality should be estimated as high incompetence and integrity. The attributes shape the foundation for evaluating risks at the level of financial statement and gathering facts on audit engagements. Jos A. Bank being a cloth line company, and there are various risks of development of scandals in the business. These are aggravated by the nature of the business. The major factors are those that can lead into fraud and they include the nature of the items in the company, ease with which one can resale the products of the company outside is major risk factor for fraud. The value of the clothes is not so high per piece that makes it easier for the incident of fraud because of the ease with which the products can be gotten out of the premise due to their size. The nature of the environment in the business also is among the risk factors of fraud. There are

Wednesday, August 28, 2019

Death of a loved one and identity Essay Example | Topics and Well Written Essays - 2750 words

Death of a loved one and identity - Essay Example The main reasons given about the change of identity concern the aspects of religion, psychological perspectives, and interpersonal relationships. From the perspective of religion, it would be noted that a persons religious identity and spiritual affiliations are the most probable aspect that can be changed. This essay, â€Å"Death of a Loved One and Persoanl Identity,† is a critical analysis of the impact of the death of a loved one, and the effect it has in the identification of the personality of a person. Olver (2002) explains that death is an old phenomenon, and it has always existed. Many people are afraid of death, and this is the reason there is extensive debate on how to prevent it, and the life of an individual after death. However, there are different beliefs about this concept of death, and this depends on the values and status of an individual. Earle, Komaromy, and Bartholomew (2009) explain that religion plays a role in explaining the concept of death, and the impact it has on an individual. For instance, religious people believe that, once an individual dies, then he or she has a next life. This life depends on the religious belief of an individual, for instance the Buddhists believe in re-incarnation, while Christians believe in ascension to heaven once an individ ual dies. However, scientists do not have such kind of beliefs, and this is because they are motivated by facts in trying to explain this aspect of death, and the consequences it has in the identification of the personality of an individual. The lack of concrete evidence on this aspect of resurrection has made this topic ambiguous, and difficult to explain. This is because of lack of stories on people who have resurrected, hence giving an account of what happens after death. Therefore, a person can only experience this concept of death, through a third party. That is an individual who is grieving, or has just lost a loved one. The loss of a loved one, normally leads to a

Tuesday, August 27, 2019

Solution on how engineering text books could be made affordable to Essay - 1

Solution on how engineering text books could be made affordable to mechanical engineering students - Essay Example Amadallo D.1 argues that, "I could have performed much better than I am doing now if all or at least a good fraction of the text books I've always needed were made available. My grades are affected negatively by the fact that I do not have most of the recommended books". Asked to explain why this is so, the student claims that though the texts are available in the stores, the price tag on each is disappointing! The cry of this student reflects that of the many students taking the course in the many higher institutions of learning all over the world. There is need to find a solution to this "price tag" problem, so that we can be certain that the future mechanical engineers are trained appropriately as per the demands of their dynamic field. Publishers of the mechanical engineering books on the other hand do not see any unjustifiable reasons for the high costs of the products; the books have higher production costs anyway, even in terms of quality production as compared to the other fields! The scope or range of material that a particular book customary includes and the contents, referring to the subjects or topics usually covered in any engineering book directly implies higher costs (D. W. King and C Tenopir.1999). The publishers claim that the blame should be laid on the stringent authorship restrictions, the policy imposing the limitations on who is eligible to submit any material for publication, which renders the field duly uncompetitive. The expensive acquisition of the many international publications that enjoy well deserved reputation, regional disparities that might exist, for example, addressing a methodological topic having little relevance elsewhere and high editing costs are also to blame. Students on the o ther hand do no agree with the claims laid by the publishers. They blame the publishers of taking advantage of the belief that the course is generally expensive citing the current price of a new algebra textbook approaching $110 with the publishers bringing out a new edition every three to four years just to prevent students from selling their used books (digg, 2006). The quality of the text contents should never be compromised and the validity of the authors should even be exposed to more stringent rules to protect the authenticity of any publications made. The students argue that techniques should be devised to make the unaffordable texts available to the students who need them, and this basically involves a modulation of the publishing costs. This can, for example be achieved by introducing mergers where senior engineering students and any willing departmental lecturers and scholars with a motivation to engage in the business of publishing are involved in editing, marketing or in sales and in any other aspect related to publishing operations, as a cost sharing initiative between the publishers of mechanical engineering text books and mechanical engineering students. To facilitate the provision of high quality and latest text books to the students at reasonable costs, it has been proposed that the books recommended for each course in the entrusted curriculum should be adopted as textbooks by all the universities (Revised Curriculum of Mechanical Engineering, 2003). The need for technical speciality is another major reason that contributes to the high cost of

Monday, August 26, 2019

Marketing Essay Example | Topics and Well Written Essays - 3000 words - 18

Marketing - Essay Example strategies need to be formulated or optimally oriented as part of marketing orientation, so that organisation can reach maximum customers, entice them and importantly build long-term relationship, thereby retaining them. As the above mentioned country specific aspects need to be mainly analyzed in relation with the product that is going to be launched, the product’s profile should ‘fit’ with the consumer of that particular market. Although, it applies to all product range, it is of utmost importance to luxury brands including luxury handbags. A luxury brand is a lifestyle concept that is mainly designed for an exclusive consumer base, even while enticing a wider consumer base. Vickers and Renand (2003) observe that luxury goods are adapted versions of base products which are manufactured according to consumer needs and tastes, and there are three dimensions to these products, and it applies to luxury handbags as well. The three levels of luxury products are, first, the inaccessible luxury products, which are only or mainly for the elite or affluent, as the other classes will find it difficult to buy it. Then, comes the intermediate luxury products, which for the professionals who are financially equipped to buy those products and thereby fulfil their desire to attain the status of the affluent. Finally, there are accessible luxury products for the middle class, which will be set in a feasible price range. Prospective customers in each of these levels have to be enticed through level-specific marketing strategies. So, on the whole it is necessary to grasp the consumer behaviour regarding particular products, along with other environmental forces. So, from the above understanding, it is clear that, to launch the new range of luxury handbags in UK, the macro and the micro environment as well as the consumer behaviour in the UK market has to be analyzed, based on which consumer and market oriented relationship marketing strategies can be formulated. The

Sunday, August 25, 2019

HATE CRIME Essay Example | Topics and Well Written Essays - 1500 words

HATE CRIME - Essay Example According to Dr. Jack McDevitt, hate crimes are â€Å"message crimes,† which tell the victim and the minority group to which he belongs, that they are not welcome in that society (cited in APA Position paper, 1998). As such, hate crimes have the potential to alienate whole sections of society and lead to fragmentation. In the face of such clear-cut danger to society, it is imperative that unambiguous, punitive legislation against hate crimes needs to be enacted and put into execution at the earliest. The entry of the term ‘hate crimes’ into common vocabulary can be traced to the Justice Departments’ ‘hate crime statistics’ in 1985 (Jacobs and Potter, cited in Siasoco, 1999). The official definition of a hate crime or a bias crime is â€Å"a criminal offense committed against a person, property or society which is motivated, in whole or in part, by the offenders’ bias against a race, religion, disability, sexual orientation or ethnicity/national origin† (Robinson, 2003). The perpetrators of hate crimes are generally young adults and strangers to the victims. While some of them may be members of hate groups such as the Ku Klux Klan, the vast majority are otherwise law-abiding individuals, whose personal biases stem from the social norms governing their environment. They often feel that they are morally justified and supported by society in their attacks on people perceived to be ‘different.’ The leading basis of hate crimes continues to be racism, with African-Americans bearing the brunt of the attacks, a particularly heinous case being the dragging to death of James Byrd in Texas in June 1998. Ethnic minorities are targeted because of their different lifestyles and their success being perceived as a threat to the employment and financial opportunities of the ‘natives.’ David Ritcheson, a Latino, was sodomized and savagely

Saturday, August 24, 2019

Some of the Routine Applications of Descriptive Statistics Coursework - 12

Some of the Routine Applications of Descriptive Statistics - Coursework Example In addition, Part B of the assignment discusses some of the use of confidence intervals in determining the statistical confidence of nursing research and explains that the approach is used test the reliability or probability of getting the same values from a sample size. However, a major controversy of statistical and clinical significance is the biasness of the resulting data when used in real clinical context. The descriptive statistics in the article stems from the emphasis on the need to identify and include or integrate the family members of the patients during the provision of the health care services to the patient (Tudor, Berger, Polivka, Chlebowy & Thomas, 2014). As such, the article recommends there is the need to embrace patient and family-centered care as this is poised to transform the healthcare sector a great deal. In particular, the article tries to gather descriptive statistics from the characteristics or elements of the patient’s family members with the underlying assumption that involving the family of the patients in routine care can improve safety and satisfaction (Tudor, Berger, Polivka, Chlebowy & Thomas, 2014). In this case, the descriptive statistics included such elements like the ethnicity, sex, age, years of experience, work unit including other important statistics on the characteristics of the patient’s family like specialty certification, the num ber of times they have been involved in resuscitation (Tudor, Berger, Polivka, Chlebowy, Thomas, 2014). Other variable statistics included or involved identifying the risk and benefits of the presence of the family.

Friday, August 23, 2019

UK Music Retailers Assignment Example | Topics and Well Written Essays - 2500 words

UK Music Retailers - Assignment Example Businesses operating in any industry are bound to experience changing fortunes in so far as trade is concerned. There are several forces that play in the economy thus influencing the fate of each of the entities in a given sector. With this in mind, it is the sole responsibility for individual business organizations to examine factors within their environment and identify the interventions to keep it competitive. I further use interaction matrix to analyze how the business has changed over time. Finally, I conclude by comparing two players in this music sector and offer some appropriate recommendations. Just like in any other economy of the world, the UK economy also suffers from quite a number of challenges. Being an important component of the economy, UK retailers have not been spared from the difficult moments that occasionally characterize the economy. Therefore, some traditional UK retailers such as music retailers who deal with the selling of music CD and VCD have been critically affected. In the past few years, some famous music retailers went bankrupt one after another. Cases in point include the Towers, KPS, and Virgin. Whilst some of the aforementioned retailers were troubled by the market changes, the likes of Find-CD, which is an online music company, were flourishing (Traynor, 2013). According to the findings of Traynor (2013) in his research, nearly 140 music retailers are prone to the perilous economic period in the near future. A case in point is the HMV music retailer. HMV is credited for having been one of the longest-serving players in the music industry with a history of music retailing of approximately 91 years. It deals with the sale of CDs/DVDs containing music, movies, or video games.  

Accounting and finance for Managers Essay Example | Topics and Well Written Essays - 1500 words

Accounting and finance for Managers - Essay Example Capital structure decisions are significant as they determine the company’s profitability and financial flexibility. Therefore, while forming capital structure plans, the financial decision maker must consider the nature of business, external & internal conditions, economic conditions and the future plan of a company. This paper will attempt to analyse the capital structure policies of a public company (listed on stock exchange) along with the merits and demerits of capital structure. The primary focus of this paper will be to evaluate the capital structure policies of the company in context of relevant capital structure theories. The initial sections will have a brief discussion on various capital structure theories. This will be followed by a brief overview of the selected public company so as to understand its nature of business and the prevailing capital structure policy of the company. The overall findings of the project will be discussed in the concluding section. Designing the capital structure of a public company is very much crucial as it helps to reduce financial risk. Besides, the financial managers have to keep redesigning the company’s capital structure for maintaining proper leverage. Gerestonbeg has defined capital structure of a company as â€Å"the composition or make-up of its capitalization† that includes â€Å"all long-term capital resources i.e. loans, reserves, shares and bonds† (Patra, 2006, p.237). Many scholars have developed various capital structure theories for trading off between the owned capital and loaned capital. Some of popular theories of capital structure are trade off theory, pecking order theory, agency cost theory and Modigliani & Miller theory. Out of these theories, Modigliani & Miller theory is the most important and widely accepted capital structure theory. In order to trade off between costs and benefit of debts, the financial managers must choose the optimum level of capital structur e. The cost of capital

Thursday, August 22, 2019

Sample of Detailed Job Description of Health Care Assistant Essay Example for Free

Sample of Detailed Job Description of Health Care Assistant Essay In the morning the role of the Healthcare Assistant is to assist the Nursing Staff in the delivery of Patients care , under the supervision of Clinical Nurse Manager and Staff Nurse. Before handling the clients Health Care Assistant under Inspection and Prevention Control by Washing or Disinfecting hands must be follow. Health Care Assistant will assist the client during bathing, showering, shaving, dressing and undressing in bed and in the bathroom under the supervision of the Nurse. Privacy and Dignity must be respected and full Independence are implemented in all clients and those not able. Health Care Assistant will help the Nurse to serve clients breakfast and to feed those who are helpless, under the supervision of the Nurse. Privacy and Dignity must taken place and full Independence must be delivered to the clients. Health Care Assistant will follow individual patients dietary needs are adhered including special diets and give supplementary drinks under the direction of the Nursing Staff. Health Care Assistant will assist the Nurse in bed making. Health Care Assistant will collect dirty sheets, duvet covers, bed covers and patients dirty cloths under the guidelines of Linen Management/Disposal put them to their respective laundry bag for porter to be collected. Health Care Assistant will answer bell calls and assist patients who are confined to bed with their toilet needs under the supervision of the Nurse. Health Care Assistant will assist in toileting of patients including the giving, removing and emptying of bedpans, urinals, commodes under the supervision of the Nurse. Health Care Assistant will clean and disinfect bedpans, urinals, commodes, hoist, shower seats and trolleys under the guidelines of Infection control and Prevention. Guidelines of Infection and Prevention control must be follow. Health Care Assistant will tidy bathrooms, sluices and toilets. Mop up spillages on the floors under the guidelines of Waste Management/Disposal. Disposed of soiled linen in water soluble bag securely and seal place it in white canvas bag for transfer to hospital sluicing department. Pack soiled woolens in separate water soluble bags place it in blue plastic bag for laundry. Health Care Assistant will serve dinner to patients at 1 o’clock and feed those are helpless under the supervision of the Nurse. Monitor patients intake to avoid choking. Clean and wash if necessary bed-tables and lockers. Remove rubbish etc. Health Care Assistant will answer call bells and report request to Nursing staff. Health Care Assistant will assist in toileting of patients including the giving, removing and emptying of bedpans, urinals, commodes under the supervision of the Nurse. Always maintain privacy and dignity towards patients. Answer telephone calls and locate appropriate personnel, as required. Health Care Assistant if necessary will assist with the transport of patients in the wards or transfer patients to other departments as required under the supervision of the Line Manager or Nurse in Charge. Health Care Assistant during Admission, transfer or discharge list patients property under the supervision of the nurse in charge. Health Care Assistant will serve tea and feed those who are helpless. Health Care Assistant will assist the patients back to bed under the supervision of the Nurse. Always maintain privacy,dignity and respect to patients. Remember, patients has the right to refuse. Remove uniform and disinfect hands before leaving the ward. 2/2 As a night Healthcare Assistant the role is to assist the night Nurse in the delivery of the the Patients care, under the supervision of the night Superintendent. Collect dishes and wash them. Ensure that kitchen are keep tidy and locked at all times. Answer call bells and report request to nurse on duty. Assist patients those who wants to go to the toilet or offer bedpans and commodes to those who needs before bed. Assist patients back to bed. Always maintain privacy, dignity and respect at all times. Remember patients has the right to refuse. Assist patients and ensure that call bells are working properly at patients reach. Ensure all doors and windows are lock and all Fire exit doors are clear with no obstruction. Monitor patients at all times, ensure that patients are in safe and in comfortable way. Emptying and disinfects commodes, urinal bottles and bedpans after use. Be alert at all times. Ensure safety and security of all the patients at night. Answer call bells and report request to nurse on duty. Incontinence patients are more likely to be wet at night.Ensure they are dry at all times. Change pad and linen if necessary under the supervision of the night Nurse on duty. Always maintain privacy, dignity and respect towards patients.

Wednesday, August 21, 2019

An Introduction To DNA

An Introduction To DNA DNA (deoxyribonucleic acid) is the genetic material of eve living organisms including some viruses. It is a dimer consists of two strands that immerse upon each other and appear as a double helix that are linked together covalently with each other. Each strand is made up of similar repeating units called nucleotides. Each nucleotide composed of three different moieties,a 2-deoxyribose sugar,a phosphate group and a nitrogenous base. 1.1.1 2-Deoxyribose sugar The 2-deoxyribose sugar, a major structural component of DNA is a cyclic molecule .The sugars are joined together by phosphate groups that form phosphodiester bonds between third and fifth carbon atoms of adjacent sugar rings.The 5 carbon of deoxyribose sugar is attached to the 3 carbon of the next, and make a network of 3 carbon and 5 carbon.5end of a DNA molecule is characterized by a free phosphate (P) group and the 3 end is characterized by a free hydroxyl (OH) group. It lacks an hydroxyl group at the 2 position as in a ribose therefore a sugar moiety is a 2-deoxyribose. Two free hydroxyl groups are also located on the 5 carbon and 3-carbon of 2-deoxyribose sugar.These hydroxyl groups give a DNA oligomer its designation of 5 and the 3 end(usually accent as three prime end and five prime end). 1.1.2 Sugar-Phosphate backbone The 2-deoxyribose sugar and a phosphate group forms the backbone in the DNA which are highly polar and defines directionality of the molecule. The polar hydrophilic back- bone is surrounded by a core of hydrophobic bases and is important for the stability and structure of DNA. The phosphate groups have a negative charge that gives a concentra- tion of negative charge on the backbone of DNA and also makes DNA,a negatively charge 5 1 Fundamentals molecule. The charge is also neutralised by DNA-binding proteins that contain the pos- itively charged amino acids lysine and arginine, which are attracted to the negatively charged phosphate backbone. See Fig. 1.1. Figure 1.1: DNA backbone 1.1.3 Nucleic acid bases DNA contain four different nitrogenous bases that make monomer of one nucleotide different from other. These bases are adenine (A), thymine (T), cytosine (C), and gua- nine(G). The bases come in two categories pyrimidines and purines. Larger nucleic acids adenine and guanine are members of a class of doubly ringed structures called purines while the smaller nucleic acids cytosine and thymine are members of a class of singly- ringed chemical structures called pyrimidines .A six-membered ring with two-nitrogen molecule formed a pyrimidine structure whereas purine is produced by a nine-membered, ring with four- nitrogen molecule. Each unit of the ring constructing the base is numbered to for specific identification. They are arranged in a particular order along the backbone of DNA to make a long chain of varying sequence that contains the code for proteins.The sequence specifies the exact genetic instructions required to create a particular organism with its own unique traits. 6 1 Fundamentals 1.1.4 Base Pairing in DNA The nitrogenous bases are responsible to form double-strand of DNA in consequence of weak hydrogen bonds and have specific shapes and hydrogen bond properties. The three hydrogen bonds form between guanine and cytosine and then denoted as G.C or C.G,depending on which is associated with the first strand. Similarly adenine and thymine also bond exclusively by pairing of two hydrogen bonds and then denoted as A.T or T.A. This coupling up of nitrogen bases termed as complementarity.,A hydrogen bond donor need an equivalent hydrogen bond acceptor to form a hydrogen bond in the base across from it. Purines are only complementary with pyrimidines because molecules in pyrimidine-pyrimidine pairings are very far from each other that doesnt makes the hydrogen bonding to be established. Purine-purine pairing are energetically unfavourable because the molecules are too close and create an electrostatic repulsion. The only possible pairings are GT and AC. Primary and secondary amine groups or hy droxyl groups are common hydrogen bond donar while carbonyl and tertiary amines are common hydrogen bond acceptor groups. There are two hydrogen bonds between an A:T base pair. One hydrogen bond lie between the 6 primary amine of adenine and the 4 carbonyl of thymine. The other hydrogen bond form between the 1 tertiary amine of adenine and the 2 secondary amine of thymine. On the other hand,G:C base pair has three hydrogen bonds. One hydrogen bond lie between guanine with its 6 hydrogen bond accepting carbonyl and cytosine having 4 hydrogen bond accepting primary amine. The second hydrogen bond also formed between guanine on 1 secondary amine and cytosine 3 tertiary amine and the third formed between the 2 primary amine on guanine and the 2 carbonyl on cytosine. 1.1.5 Directionality The directionality of DNA is vitally important to many cellular processes. since,double helices are necessarily directional(a strand running 5 to 3 pairs with strand running 3 to 5 )and processes such as DNA replication occur in only one direction. The two DNA strands in a duplex are anti parallel and form a chemically stable structure. That is, one strand running from the 5-phosphate to 3-OH is paired with the other strand arranged with its 3-OH opposite the 5-phosphate of the first strand, and its 5-phosphate opposite the 3- OH of the first strand. 7 1 Fundamentals 1.1.6 3 end and 5 en DNA strand is inherently directional.The 3 prime end has a free hydroxyl (or phos- phate) on a 3 carbon and is called as the tail end. New nucleic acid molecules are formed by one end of 3-hydroxyl as it is ligated to the other end of 5-phosphate of a different nucleotide that make it possible to form strands of connected nucleotides.Molecular biologists can use nucleotides that has a deficiency of 3-hydroxyl(dideoxyribonucleotides) to stop DNA replication .The 5 prime end has a free hydroxyl (or phosphate) on a 5 carbon in the sugar-ring and this end is called as the tail end . If a phosphate group bind with the 5 end, ligation of two nucleotides can form, with a phosphodiester bond from the 5-phosphate group to the 3-hydroxyl end of other nucleotide. ligation can also stop if the above process is eliminated. Molecular biologists have an advantage of the above phenomenon to stop ligation of any unnecessary nucleic acid by removing the 5-phosphate with a phosphatase. 1.2 DNA-Ligand Binding The structure of DNA represents a variety of sites where ligands may interact and bind with DNA.The binding interaction between a drug and DNA often leads to a signi_- cant modi_cation of the structure of the DNA and may have an important inuence on their physiological functions associated with several biological e_ects including antivi- ral,antibacterial,antipotozoal and antitumor. Modes of Binding Because of the complex double-helical structure of DNA,drug molecule interact with DNA in a number of modes. A number of forces of varying strength involved in each interaction. Electrostatic forces with the phosphate backbone,sequence sensitive van der Waals interaction and hydrogen bonding interactions that occur between polar atom of bases and hydrogen molecules are incorporated singly or in combination.To understand the mechanism of interaction of each mode,it is best to discuss di_erent binding modes that can act on DNA. (a) External Binding (b) Intercalators (c) Groove binding (i) Major groove binders (ii)Minor groove binders External Binding This type of binding results due to electrostatic forces applied to the negatively charge phosphodiester group along the backbone of DNA for cationic molecule.Ligand charge, hydrophobicity and size a_ect on electrostatic interactions.External binding may also be due to either covalent or non-covalent interactions.This mode of binding is characteristics for major groocould potentially be sampled during simulations where the charge and shape of helical molecules are both changed. Intercalators An important class of molecules that binds to DNA are intercalators,which have been extensively used as a anti-cancer drug.Intercalation occurs due to immersion of a at aromatic drug molecule between nucleic bases contributes to unwind DNA helix(67).The interaction between a positively charged intercalator and a negatively charged DNA can be quite strong and form complex through electrostatic forces.Energy consumed to unstacked the nucleic acid bases which forms a gap between neighbouring base pairs into which the intercalator can _t easily.Because of small binding site,they have a little sequence selectivity and many known intercalators shows limited selectivity for GC base pairs such as ethidium bromide which has a high a_nity towards GC site.Several other drugs such as propidium,proavin, anti-tumor drugs adriamycin and actinomycin D intercalate with DNA. Groove Binders Smaller ligands preferentially binds to minor groove region whereas proteins and other large molecules speci_cally _ts into the major groove region of DNA. They have crescent -shaped conformation due to presence of two or more than two aromatic rings that gives a conformational exibility to the molecule and makes it perfect to _t in the groove. They also possess some functional group that forms hydrogen bonds at lower most part of DNA bases.They perfectly accommodate in the AT rich regions but some known groove binders show little preference towards GC site. Major Groove binders Presence of number of hydrogen bonds on the DNA major groove enhance its recognition potential. Major groove speci_c compounds are alkylating and methylating agents and and N 7 position of guanine in the major groove take part in interaction.one of the most common example is Cis platin which is a well known anti cancer drug. Minor Groove binders The most widely studied DNA interacting agents are minor groove binders that occurs naturally and also synthesize according to their sequence speci_c properties as they have pronounced binding a_nity towards AT rich groove.AT binding site is more thinner and deeper than GC so that all heteroaromatic rings such as furan,pyrole,benzene and Imidazole of minor groove binders twisted and _t better into AT site by applying van der waals force.Hydrogen bonds of bound molecule attached to the AT base pairs to the C-2 carbonyl oxygen of thymine or N-3 nitrogen of adenine.GC base pairs also contain same functional groups but a steric block form by amino group of guanine in GC locations which causes hinderence to the formation of hydrogen bond on guanine at N-3 position and on cytosine at O-2 cabonyl position,prohibiting vad derWaal forces and inhibit penetration of small molecules at GC sites of minor groove.AT site selectivity for positively charged minor groove binders also enhanced due to high negative electrostatic potential as compared to GC site. A number of experimental studies shows that minor groove of B type of DNA duplexes more suitable for binding of small molecules most often with Dickerson-Drew sequence d(CGCGAATTCGCG) and also similar such as d(CGCAAATTTGCG). 1.3.1 Berenil X-ray crystallography proof complex formation of berenil with dodecanucleotides,i.e. d(CGCGAATTCGCG) and d(CGCAAATTTGCG)which in turn shows its preference of binding with AT rich site of DNA minor groove and reside between three (AAT) or four(AATT) base pairs. A number of research on berenil also con_rm its weak interac- tion and intercalating behavior.Hydrogen bonds are also formed between the amidinium groups and adenine N-3 or thymine O2 atoms on reverse strands of a double helical DNA oligonucleotide.Berenil is a curve shape drug which match the helical structure of DNA minor groove. 1.3.2 Pentamidine One of the most clinically important drug,pentamidine is a synthetic antimicrobial com- pound also known aspentamidine (1,5-bis(4-amidinophenoxy)pentane,among all the mi- nor groove binders.It has been use as a secondary drug for treating aids related P.carinii pneumonia.Foot printing and X-ray crystallography shows its pronounced attachment to DNA sites which has minimum four to _ve successive AT base pairs with the charged amidinium group shows hydrogen bonding to O2 of thymine or N3 of adenine on oppo- site DNA strands. It contains two phenyl rings that are twisted after binding with the minor groove by 35ÂÂ ° with respect to each other by van der Waals forces. 1.3.3 DAPI DAPI also called 4,6-diamidino-2-phenylindole(DAPI) is a synthetic,unfused aromatic compound is widely used in molecular biology as a uorochrome on binding upon AT site of minor groove binder as well as an intercalating drug.upon binding to GC rich sequence without showing any property of uorescence.X-ray structure of DAPI with d(CGCGAATTCGCG)exhibited that the drug span three base pairs and also give a clear picture of parallel attachment of phenyl and indole rings to the minor groove walls of DNA. |||||||| 1.4 UV-Visible Spectroscopy Spectroscopy is a valuable tool in the study of intermolecular interactions. It is a well developed routine technique and plays an important role in analytical chemistry as well as it has widespread application in physics and life sciences. It deals with the mea- surement of the absorption of radiations in the ultraviolet and visible region of spec- trum.Spectroscopic techniques form the largest and the most important single group of techniques used in analytical chemistry,and provide a wide range of quantitative and qualitative information. All spectroscopic techniques depend on the emission or ab- sorption of electromagnetic radiations and used to determine the electronic structure of atoms and molecules. In order to understand these techniques,it is necessary to have some knowledge about properties of electromagnetic radiations and the nature of atomic and molecular energy. The ultraviolet region extends from 10 to 400nm.It is subdivided into near ultraviolet region (200 to 400nm) and the far or vacuum ultraviolet region(10 to 200 nm).The visible region extends from 400 to 800 nm. 1.4.1 Electromagnetic radiations Electromagnetic radiations are produced by the oscillation of electric charge and mag- netic _eld residing on the atom and has its origins in atomic and molecular processes. It vibrates perpendicular to the direction of propagation with a wave motion and can travel in space and does not need a medium like air or water to travel through. There are various forms of electromagnetic radiations e.g. visible,ultraviolet,infra-red, X-rays,microwaves and cosmic rays. They are characterised by frequencies,wavelength or wave numbers. The most familiar form of electromagnetic radiations is visible light which forms only a small portion of full electromagnetic spectrum. Electromagnetic spectrum A plot which shows a number of absorption bands with respect to energy versus wave- length has some properties yield various information and is broken into several regions called as Electromagnetic Spectrum.Di_erent regions of the electromagnetic spectrum provide di_erent kinds of information as a result of interactions. Electromagnetic spec- trum covers a very wide range of electromagnetic radiation that starts from gamma rays and ends on to radio waves. The boundaries between the regions are approximate and the molecular process associated with each region are quite di_erent.The regions in increasing order of frequency are 1/ Radio frequency region ;Nuclear magnetic resonance and electron spin resonance spectroscopy.The energy changes with change in direction of spin of a nucleus and elec- tron. 2/ Micro wave region:Rotational spectroscopy .Change in energy arise from transi- tions to higher energy associated with change in the rotational quantum number of the molecule. 3/Infra-red region:Vibrational spectroscopy The energy changes associated with transitions between vibrational levels of molecules. 4/Vis- ible and Ultraviolet region:Electronic spectroscopy The energy changes accom- pained with valence electrons of molecules. 5/X-ray region: inner electrons of an atom or a molecule invole in order to change energy of molecule. 6/ X-ray region: nuclear excitations necessary for an enegy change. 1.4.2 Law of molecular Absorption:Beer-Lambert law All spectrophotometric methods that measure concentration in terms of absorbance,including detection of proteins and nucleic acids,determine molar absorptivity of metal com- plex,various enzyme essay,describe attenuation of solar or stellar radiation and di_er- ent metabolites based upon two basic rules,which combinely spoken as Beer-Lambert law.This law was basically originate by a French mathematician Lambert,which states that the function of light absorbed by a transparent medium s independent of the inci- dent light assing through it.This shows that logarithm of the decrease in light intensity along the light path with respect to thickness of medium which can be written as follow log10(I0/I) = kl where IÂÂ ° is incident light intensity,I is light path length,k is a medium constant which is further interpret by a Beer,a German Physicist in the same year states that the amountof light absorbed is proportional to the number of molecules of the chromophore through which the light passes.One can also says that constant K is directly proportional to the chromophore concentration i.e. K=eC,e is the molar absorptivity of chromophore and is equal to absorption of 1M of solution at a path length of 1 cm and their unit is M-1cm-1.Now,combinely Lambert-Beer law presented as A = lC, whereby,the term log10(I0/I) is re_ered as absorbance(A),l is the thickness of solution and E is the molar absorption coe_cient. 1.4.3 Electonic transitions in Nucleic Acids Absorption or emission of radiations in nucleic acid causes di_erent types of transitions in UV-visible spectral regions and appear from n-pi* and pi -pi* transitions of purine and pyramidine bases. -* transition Large amount of energy required for the shifting of an electron from a bonding molec- ular orbital to a * antibonding molecular orbital in the UV region.Unsaturated hydro- carbons shows this type of transition and being transprent in the near UV such as methane,heptane and cyclohexane that shows maximum absorbance below 200 nm due to the fact that absorbance is equal to 1 for a thickness of 1 cm below 200nm. Similarly, water in the near UV(A=0.01 for 1cm ,at lambda =190nm)is transparent due to the presence of -* and n-* transitions. n- *transition This type of transition usually occur in compounds having lone pair of electrons and required energy lower than -* transition for the promotion of an n electron from an atom to an * molecular orbital.Moderate wavelength range for this transition is 150 to 250 nm as 180nm for alcohols,near 190nm for ethers or halogen derivatives and in the region of 220nm for amines. *transition Most of the organic compounds have a conjugate system and shows -* transitions with an intense strong absorption band occuring anywhere in the near UV region which depends upon the presence of heteroatoms substituents.These compounds also shows a slightly blue and red shift with respect to its polarity. n- *transition These bands are called forbidden bands having a low molar absorptivity less than 100 and originate from promotion of electron from a non bonding molecular orbital to an anti-bonding *orbital.This transition is more pronounced in molecules having a hetero atom with a lone pair of electron i.e.carbonyl which requires low energy and occur in the regions from 270 to 300 nm. d-d transition electrons placed in incompletely _lled d orbitals of most of the inorganic salts are re- sponsible for transitions of weak absorption and also color and located in the visible region..That is why the solutions of metallic salts of titanium or copper are blue,while potassium permeganate yeilds violet solutions, and so on. 1.4.4 Chemical shift Bathochromic shift change in max to longer wavelength(lower frequency)also change absorption,reectance transmittance or emission spectrum of a molecule mostly due to substitution or solvent e_ect i.e change in polarity of solvent called as bathochromic shift or red shift.Solvent e_ect is weak in less polar compounds as compared to polar one which can stabilise excited form,favours transition and causes a change in wavelength towards longer side. Hypsochromic shift The opposite e_ect of bathochromic shift also called as blue shift as max shift towards the blue end of spectrum.Unbonded electron pair lowers the energy of the n-orbital and increased solvation causes hysochromic shift.Mostly polar solvents such as water and alcohol have pronounce e_ect of hypsochromism due to broad hydrogen bonding between protons and the non-bonded electron pair during solvation. Hypochromic shift reduction in the intensity of uv light without any change in wavelength called as hypochormic e_ect which caused by the entry of an auxochrome which distrots the chromophore.For example ,biphenyl shows lAMDAmax 252nm,Emax19,000,whereas 2,2-dimethylbiphenyl shows Lambda max 270nm,Emax 800. Hyperchromic shift This e_ect leads to an increase in absorption of UV light at same wavelength due to appearance of an au that causes hyperchromic shift.For example,benzene shows B-band at 256nm,Emax 200,whereas aniline shows B-band AT 280nm,Emax 1430.The increase of 1230 in the value Emax of aniline compared to that of benzene is due to the hyperchromic e_ect of the auxochrome NH2. 1.4.5 Chromophore groups Organic compound mostly containing double bond is responsible to produce color and absorption of ultraviolet or visible radiations as single bond is not enough to do that but if many are present in conjugations,sharp color can produce. A single functional group or a collection of functional groups also capable for absorption and they also act as a chromophore. A complex molecule can contain more than one chromophore so the e_ect of conjugation on the chromophore is to shift the maximum absorption to a longer wavelength .i.e. a bathochromic shift or red shift appear with an increase in absorption intensity and the spectrum is strongly upset with respect to the superimposing e_ects of random chromophores. The more the number of carbon atoms on which the conjugated system is spreaded,the more the decrement in the di_erence between energy levels.and accounts large bathchromic e_ect. A very simple spectrum of a compound having one main peak absorbing below 300nm possibly contains a very simple conjugated system Instrumentation in UV-Visible Spectrophotometer UV-Visible spectrophotometer is a very simple to operate and able to perform quick qualitative as well as quantitative analysis.It is usuallay designed around _ve funda- mentals parts i.e. a radiation source,a monochromater(wavelength selector),a samplecell(cuvette),detector and a signal processor (readout device) for measuring the absorp- tion of uv or visible radiations.These components are typically integrated in a unique frame work to make spectrometers for chemical analysis.Two types of UV-Visible spec- trophotometers are generally in use:a _xed spectrophotometer with a single beam and a scanning spectrophotometer with double beams.Single beam spectrophotometers are highly sensitive devices and obtaining a spectrum requires measuring the transmittance of the sample and the blank at each wavelength separately.In the double beam spec- trophotometer,the light split into two parallel beams,each of which passes through a cell;one cell contains the sample dissolved in a solvent and the other cell contains the solvent alone.The detector measures the intensity of light transmitted through the sam- ple cell. Light source The intensity of radiation coming from the light source varies over the entire UV-Vis range.More than one type of source can be used in UV-Vis spectrophotmeter which au- tomatically swap lamps when scanning between the UV and visible range .A deutrium lamp is used for the wavelengths in the UV range,a tungsten lamp is used for the wave- lengths in the visible range and alternatively for the entire UV-Visible region,a xenon lamp can be used. Monochromator Its role is to spread the beam of light into its component wavelengths and a system of slits focuses the desired wavelength on the sample cell.The most widely used dispersing device is a prism or a grating made p of quartz because quartz is transparent throughout the UV range. Detector The detector converts the intensity of light reaching it to an electrical signal.It is by nature a single channel device.Two types of detector are used,either a photomultiplier tube or a semiconductor.For both of which the sensitivity depends upon the wavelength. QSAR and Drug design Quantitative structure-activity relationship (QSAR) (sometimes QSPR: quantitative structure-property relationship) is the process by which chemical structure is quanti- tatively correlated with a well de_ned process, such as biological activity or chemical reactivity. For example, biological activity can be expressed quantitatively as in the concentra- tion of a substance required to give a certain biological response. Additionally, when physicochemical properties or structures are expressed by numbers, one can form a math- ematical relationship, or quantitative structure-activity relationship, between the two. The mathematical expression can then be used to predict the biological response of other chemical structures. QSARs most general mathematical form is: * Activity = f(physiochemical properties and/or structural properties) Quantitative structure-activity relationships (QSAR) represent an attempt to corre- late structural or property descriptors of compounds with activities. These physico- chemical descriptors, which include parameters to account for hydrophobicity, topology, electronic properties, and steric e_ects, are determined empirically or, more recently, by computational methods. Activities used in QSAR include chemical measurements and biological assays. QSAR currently are being applied in many disciplines, with many pertaining to drug design and environmental risk assessment. Chromophore Organic compound mostly containing double bond is responsible to produce color and absorption of ultraviolet or visible radiations as single bond is not enough to do that but if many are present in conjugations,sharp color can produce. A single functional group or a collection of functional groups also capable for absorption and they also act as a chromophore. A complex molecule can contain more than one chromophore so the effect of conjugation on the chromophore is to shift the maximum absorption to a longer wavelength .i.e. a bathochromic shift or red shift appear with an increase in absorption intensity and the spectrum is strongly upset with respect to the superimposing effects of random chromophores. The more the number of carbon atoms on which the conjugated system is spreaded,the more the decrement in the difference between energy levels.and accounts large bathchromic effect. A very simple spectrum of a compound having one main peak absorbing below 300nm possibly contains a ve ry simple conjugated system such as diene or an enone whereas, if the spectrum is much mixed and also allocated in a visible region,then the molecule must contain chromophore having large red shift such as polyene ,polycyclic aromatic system etc. Solvent Effect Selection of solvent used in UV-visible spectroscopy is very important. The prime requirement for a solvent is that it should be transparent to radiation over full UV range and also not absorb UV radiations in the region of substance whose spectrum is actually analysed .Most of the organic solvents successfully meet that criteria and solvents without having any conjugtion are very convenient for this purpose.Among the solvents ,the water ,95% ethanol and hexane are most commonly used and are transparent in the full uv spectrum. Another valuable requirement for selecting a solvent is that it gives a nice spectrum of a set a absorption bands because polar solvent form hydrogen bonds with solute and the fine spectrum of the complex may vanish but this is not the case for non polar solvents where a fine spectrum often easily appears because of the absence of hydrogen bonding.Polar solvents also shows bathochromic effect which causes a decrease in electronic state. Asecond criteria for agood solvent is its effect on the fine strusture of an absorption band.Ano polar solvent doesnot hydrogen bond with the solute,and the spectrum of the solute closely approximate s the spectrum that would be produced in the gaseous state ,in which fine structure is often observed.In a polar solvent the hydrogen bonding forms a solute solvent comlex and the fine structure may disappear. Athird criteria for a good solvent is its ability to influence th

Tuesday, August 20, 2019

Resonance Frequency Analysis Tool for Implant Stability

Resonance Frequency Analysis Tool for Implant Stability Dr. Vishwanath Pattar Dr. Anjana Bagewadi MDS â€Å" Resonance frequency analysis (RFA) – A diagnostic tool for implant stability † Dental implants have become a significant aspect of tooth replacement in prosthodontic treatment. High implant success rates of the order of 78-100 % have been published, with more than 15 years of observation time. Treatment success of dental implant mainly depends on the stability of the implant bone support. Implant stability is a mechanical phenomenon which is related to the local bone quality and quantity, type of implant, and placement technique used. The application of a simple, clinically applicable, non-invasive test to assess implant stability and osseointegration is considered highly desirable. Resonance frequency analysis (RFA) is one of such techniques which is most frequently used nowadays. Aim of this paper is to review the technique of Radio frequency analysis and use of it to check the implant stability. Key words: Resonance frequency analysis, Implant stability, Implant stability quotient(ISQ) Introduction : Dental implants have reported success rates of over 90 % over long periods of time. However failures still occur and seem to be unpredictable. One factor that is being increasingly considered in failure of dental implants is occlusal loading . It has been clinically demonstrated that implant stability plays a significant role in determining treatment outcome (Sennerby Meredith 1998, Esposito et al. 1998). Implant stability can be seen as a combination of: 1). Mechanical stability, which is the result of compressed bone holding the implant tightly in place.2). Biological stability, which is the result of new bone cells forming at the site of the implant and osseointegration. Initially implant stability was measured by Surgeon’s perception while placing the implant (Insertion and seating torque), percussion testing, reverse torque test and radiographs etc. But none of them proven to be effective in measuring the implant stability. Resonance Frequency Analysis (RFA) is a non-inv asive diagnostic tool for detecting the implant stability of dental implants during the healing stages and in subsequent routine follow-up care after treatment. Advantages of Rasonance frequency analysis 1) Optimal loading decisions : It makes it easier for dentists to decide when is the optimal time to load implants. At placement, stability can be difficult to quantify objec ­tively by merely relying on tactile perception. Torque measure ­ments are difficult to repeat once the implant has started to integrate and can therefore not provide a baseline for subse ­quent comparisons. The invasive torque method may even damage the healing if used for monitoring osseointegration 2)  Early warnings – preventing failure : Dentists sometimes encounter patients whose initial stability score is low. The reason could be that they have had to undergo a bone graft. In such higher-risk situations, most surgeons would avoid an early-loading protocol. Similarly, a significant decrease in stability indicates a potential problem and should be considered an early warning. The surgeon may prefer to unload the implant – or perhaps place additional implants – and then wait until stability increases. RFA system makes the treatment of high-risk patients easier and more predictable – allowing more of these patients to be treated and more of their treatments to be successful. 3)  Quality assurance : Because RFA system helps the dentist decide when to load and avoid failure in high-risk situations, it becomes a quality-assurance system for the clinic. Most patients intuitively understand the stability measures and how they govern when to load an implant and when to wait. This increases their sense of confidence, security and quality. 4) Data can be transferable : All the stability records measured from start of the treatment and the follow –up records can be transefered from one clinician to other. It makes easy to the one clinician to communicate with other about the treatment modalities. Implant stability quotient (ISQ) ISQ (Implant Stability Quotient) is a measurement scale for use with the RFA (Resonance Frequency Analysis) method of determining implant stability. It’s a mapping of resonance frequencies (kHz), presented as a clinically useful scale of 1-100 ISQ. 1 is the least ISQ value and 100 is the highest ISQ value. ISQ is used RFA to measure stability because Supports making good decision about when to load Allows advantageous protocol choice on a patient-to-patient basis. Indicates situations in which it is best to unload Supports good communication and increased trust Provides better case documentation Instrument kit: Fig.1 Hand held probe Fig.2 MonitorFig.3 Main plug Fig.4 Data cable Fig.5 Testing device Fig.6 Smart-peg Technique : Resonance frequency analysis (RFA) uses a sophisticated technology with computer-based measurement of resonance frequency (RF), which is determined by two parameters: the degree of bone density on implant-bone interface area and the level of marginal alveolar bone around the transducer Osstell is representative of RFA-technique and was tested first in 1997The apparatus consists of an Osstell transducer and Osstell analyzer connected to a PC or independent. The transducer is L-shaped or bolts-like (smartpeg) and firmly screwed in order to be positioned on the implant and its superstructure (4–5 N/cm ²) and consists of 2 small voltage controlled transducers. High-energy pulse-type oscillations of a continuous sinusoidal pulse excite implant, in order to register the mechanical vibration between the implant interconnection zone and the bone. As soon as the apparatus is activated the first electric transducer applies excitation signal of increasing frequency from 5 to 15 kHz to implant. Other voltage-controlled element registers ultrasonic vibrations response, ie resonant frequency of the implant-bone interface area and transmits a created signal to the amplifier, which amplifies it and to the analyzer which reads, evaluates and compares it with the frequency of the original signal. The measured amplitude of resonance frequency is displayed numerically and graphically on the Osstell analyzer, and the maximum amplitude represents the stability of the implant, quantified through the ISQ units. The ISQ value reflects the rigidity of the system transducer- implant-bone and transducer calibration parameters. Measured on a scale from 0 ISQ (3500 Hz) to 100 ISQ units (8500 Hz), a higher ISQ value indicates a greater stability of the implant. After a while ISQ values rise because of osseointegration where implant–bone the connection becomes stronger. Fig. 7 Fig.8 Fig.9 ISQ values: >60 – >70 Immediate loading can be done This graph illustrates the progress of implant stability over time, expressed in ISQ terms. The converging green curves show the two most likely scenarios: implant stability eventually sets at around 70 ISQ. A high initial ISQ value tends to decrease, as mechanical stability is supplanted by osseointegration. And a low initial value tends to increase, as osseointegration sets in. The scenario to watch out for is illustrated by the red curve. Here, osseointegration is not progressing as planned, and loading such an implant may result in a failed treatment†¦ High initial stability (ISQ values of 70 and above) tends not to increase over time despitethe fact that the initial high mechanical stability decreases and is replaced by increased biological stability. Lower initial stability normally increases with time because the lower  mechanical stability is increased by the bone remodeling process (osseointegration). Values of ISQ 55 or lower should be taken as a warning sign and act ions to improve the stability should be considered (larger implant diameter, longer healing time, etc.)* *(Implant stability measurements using Resonance Frequency Analysis. Biological and biomechanical aspects and clinical implications. Periodontology 2000, 2008. Sennerby Meredith) References: Chang WA et al. A newly designed resonance frequency analysis device for dental implant stability detection ; Dent Mater J. 2007 Sep;26(5):665-71 Rajiv KG et al . Resonance frequency analysis ; Indian Journal of Dental Research, 22(4), 2011

Monday, August 19, 2019

Suppression and Subversion through Walls in Bartleby the Scrivener Es

Suppression and Subversion through Walls in â€Å"Bartleby the Scrivener† In â€Å"Bartleby the Scrivener† an elderly lawyer recounts the tenure of a scrivener, Bartleby, from his office. The progression of this employer/employee relationship depicts disengagement between opposing social classes and its consequences. The presence of the subtitle of â€Å"Bartleby the Scrivener: A Tale of Wall Street† has been given much consideration. The subtitle carries the baggage of the emerging capitalistic culture, but it also alludes to the confinement that walls enable. Melville strategically uses architecture in his short story, â€Å"Bartleby the Scrivener† to demonstrate the disengagement between social classes that capitalism produces. In the story, the narrator, representative of the upper class, controls the actual physical partition separating him and the scriveners, representative of the lower class. In the same way that he controls the sliding doors, the lawyer manipulates religion and economic factors to control the separation betwe en him and Bartleby. Architecture is also a part of Bartleby’s characterization; he is always staring at a brick wall. Melville is acknowledging Bartleby’s inability to conquer the brick wall. Melville demonstrates in the relationship between Bartleby and the lawyer that the walls that each puts up are not without consequence, ultimately leading to the death of Bartleby. Whereas capitalistic culture constructs a sky-lit window of opportunity for the lawyer, Bartleby is bound to a vision of a brick wall. Melville also uses architecture to demonstrate the ways in which each character engages and disengages with the other. Ultimately, the architecture of the social classes that a capitalistic culture produces results ... ...r hand, Bartleby is unable to conquer the confines of the lawyer, but he does find a way to manipulate them in order to subvert the authority of the lawyer. The walls that the lawyer and the scrivener use disguise the bonds of common humanity that Melville is interested in uncovering. Because the lawyer ignored the fraternal bond between them, he refused to recognize Bartleby as an individual, ultimately causing Bartleby’s erasure, through starvation. Works Cited Barnett, Louise K. â€Å"Bartleby as Alienated Worker.† Studies in Short Fiction 6.4 (1974): 379-385. Print. Marx, Karl. The Communist Manifesto. Chicago: Henry Regnery, 1954. Print. Melville, Herman. â€Å"Bartleby, the Scrivener.† Electronic Classics Series. Penn State U, 2002. 1-45. 18 Nov. 2010. Wilson, James C. â€Å" ‘Bartleby’: The Walls of Wall Street.† Arizona Quarterly 37.4 (1981): 335-346. Print.

Sunday, August 18, 2019

Business Plan :: GCSE Business Marketing Coursework

Business Plan Executive Summary Target Things is a mobile training and safety instruction company; it will utilize the DART Targeting System, a computerized range system incorporating the latest in technology and graphics. It is a 3-D range, which can be used for archery or other weapons type training. This convenient, compact and very affordable Dart digital shooting system comes in three portable cases that can be easily transported in a mid-sized vehicle. One case holds the electronic equipment, another the firearms, and the third case holds the screen/frame. Target Things will specialize in the techniques needed to become proficient with all types of archery and firearm equipment. Also, we will become firearms and archery National certified safety instructors. The electronic equipment package is enclosed in a quick set-up console that sits on the floor. The system comes with your choice of two Dart modified firearms also, over 1000 wildlife scenarios. As a secondary specialty, we will also offer instruction in gun safety and proficiency and National Bowhunter safety education course, which is required to hunt all big game animals in South Dakota and many other states with archery equipment. Introduction Target Things is intended to be a one-stop mobile target range designed to meet the archery and firearms needs of the local community and beyond. It will specialize in personal and family instructional training for the archery and firearm enthusiast while at the same time providing a specialized training operation for use by the South Dakota Department of Game, Fish and Parks Service, schools, colleges and universities, wildlife organizations, and other local and state organizations. It is very important for customers ¡Ã‚ ¦ wellness and well being. We will be able to deliver this instruction through the use of the DART mobile training and practice system and the professional knowledge of our staff. There is also a child firearm weapons available for use and they would be available for hunters ¡Ã‚ ¦ safety courses and firearms safety. This compact gun is just 30 inches in length and weighs a mere 2 pounds 4 ounces. The Cricket is ideal for young kids and can be easily handled by t hem. Hunter Education on the Dart Target System gives hunter education instructors an exciting new tool for archery and firearms education. Dart's Core Curriculum is available on all Dart Target Systems at Dart Dealers nationwide and on Dart Mobile Systems. Dart's Hunter Education & Bowhunter Education Curriculum:

Being Eleven :: English Literature Essays

Being Eleven Yep! If you are reading this you’ve probably already conquered the tumultuous eleventh year of your life. However, if you are ancient you have probably forgotten all about being eleven, so here are the advantages and disadvantages. First of all, there are many advantages of being eleven. For instance my parents trust me more. My parents let me stay home alone instead of having a babysitter. They also let me go to movies without them leading me by the hand. My parents don’t act so paranoid about me staying in the yard to play. My next positive thing about being eleven is I can go more places with my friends. For example, I don't have to go to the family skate, I can go to the friday night skate with my friends. My parents can drop us off at the front of the movie theater and we can pick what movie to watch. I can also go to the mall with a group of my friends. My third positive reason is I can choose more sports or activities. For instance, I can play tackle football instead of touch or flag football. I have the choice to play girls basketball or softball. I can also go to the school dances. My final advantage is I have more privileges. I can enter better web sites such as www.bonus.com. I can have my own e-mail address instead of writing mail by hand. My parents let me stay on the phone longer. I can stay on for about an hour instead of thirty minutes. On the other hand, there are several disadvantages of being eleven. For example, I have more chores around the house. When I come home, I always have to do the dishes instead of playing. I also have to do the laundry at night on weekdays and weekends. I have to mow the lawn every time it grows. My next example is I have harsher punishments. When I get in trouble I am either grounded for a week or even two. I also have to do all the chores when I am grounded. Another thing is I can’t go outside, play on the play station or watch television. As another example, I don't get to vote. When election time comes I can’t have a say in who I want to run my country. Being Eleven :: English Literature Essays Being Eleven Yep! If you are reading this you’ve probably already conquered the tumultuous eleventh year of your life. However, if you are ancient you have probably forgotten all about being eleven, so here are the advantages and disadvantages. First of all, there are many advantages of being eleven. For instance my parents trust me more. My parents let me stay home alone instead of having a babysitter. They also let me go to movies without them leading me by the hand. My parents don’t act so paranoid about me staying in the yard to play. My next positive thing about being eleven is I can go more places with my friends. For example, I don't have to go to the family skate, I can go to the friday night skate with my friends. My parents can drop us off at the front of the movie theater and we can pick what movie to watch. I can also go to the mall with a group of my friends. My third positive reason is I can choose more sports or activities. For instance, I can play tackle football instead of touch or flag football. I have the choice to play girls basketball or softball. I can also go to the school dances. My final advantage is I have more privileges. I can enter better web sites such as www.bonus.com. I can have my own e-mail address instead of writing mail by hand. My parents let me stay on the phone longer. I can stay on for about an hour instead of thirty minutes. On the other hand, there are several disadvantages of being eleven. For example, I have more chores around the house. When I come home, I always have to do the dishes instead of playing. I also have to do the laundry at night on weekdays and weekends. I have to mow the lawn every time it grows. My next example is I have harsher punishments. When I get in trouble I am either grounded for a week or even two. I also have to do all the chores when I am grounded. Another thing is I can’t go outside, play on the play station or watch television. As another example, I don't get to vote. When election time comes I can’t have a say in who I want to run my country.

Saturday, August 17, 2019

Merits and Demerits of Police Identification

?Discuss any four types of police identification parade emphasizing on their respective merits and short comings. Police identification parade can be referred to as a situation whereby suspects believed to have committed a crime are presented or lined-up for witnesses to identify if indeed the one or group of persons who committed the crime is amongst the line-up. This method is used inorder to help the police confirm if indeed suspect did commit the crime. There are several ways in which police identification parades can be conducted.Depending on the type of situation and resources available for use; be it human or technological will most preferably assist the police on what methods to put in (type of identification parade). When police forces are carrying out their functions, they also have a duty to have regard to the need to eliminate unlawful discrimination, harassment and victimisation and to take steps to foster good relations. The main focus of my study is to address only fou r of these identification parades and analyze into detail their main objectives and discuss their merits and where they fall short.Some of the identification parades we know of may weigh in different levels with regards to effectiveness. Others are judged to be more effective whiles some others are least effective. In this code, identification by an eye-witness arises when a witness who has seen the offender committing the crime and is given an opportunity to identify a person suspected of involvement in the offence in a video identification or similar procedure. From a legal point of view the question that an identification parade attempts to answer is whether the suspect is in fact the culprit.First of all, I would like to discuss about the ‘video identification’. With this method, suspects are kept in a confined area or room under a surveillance camera. A ‘video identification’ is when the witness is shown moving images of a known suspect, together with similar images of others who resemble the suspect. Sometimes in absence of the videos photographs of assumed suspects are shown to the witness to help identify the culprit. Even though it is sometimes useful, it is not the best since it shows still-life images which shows only one sided angle on the view of things and thereby makes it difficult for identification.The video is more advantageous in suspect identification because since there are moving images and gives different angles on the view of things. Examples are; the different kinds of expressions and mood swings exhibited by, the witness can easily identify the suspect if indeed he o she is part. These eye-witness identification procedures are designed to test an eye witness’ ability to identify suspects and to provide safeguards against mistaken identity. Secondly, the identification parade that will be considered here is the ‘line-up’.With this procedure, suspects are arranged or lined up for witnesses t o view and see which of them are or is the culprit. Here, the police officer in charge instructs the suspects to turn to whichever direction the witness asks. The witness is therefore asked to point out to the real culprit(s) who indeed committed the crime. Since this is an open parade, things could get complicated and physical in the sense that, if the witness pin points the suspect, and tempers are not calm, the suspect might step forward and harass the witness physically.In some cases, witnesses might be forced to give false data when they stare directly into faces of the suspects. Some suspects make facial expressions which are very threatening to witnesses and therefore conclude that the witness is not part of the parade for fear for their life. In other cases too, the witness might point to the wrong person who also has an appearance like that of a criminal (shabbily dressed, muscular, bony face, black lips) . Also depending on the type of question the witness is asked, he or she might give false information.Example: if the police asks; â€Å"which of them attacked you or committed the offence? † the witness is implied to just chose a suspect even if, the real culprit is not among the parade. Such questions are imperatives which do not really ask a direct question but instead expects you to comply or conform. Apart from this method shortcoming, there is no doubt that it’s sometimes reliable. Thirdly, identifications can be carried out by using a one-way mirror which is a better procedure as compared to that of the open line-ups.With this method, suspects are lined up in a room which is much secured with glass windows from which the witness can have a clear view of all the suspects present. The windows here are made of glass which are tinted, so suspects do not see whatever that goes on outside but the witness who is outside the room sees all that goes on inside. Identification of culprit(s) becomes difficult for the witness if suspects are dressed in almost the same way and there is the chance that, there exist some similarities between any of the suspects, especially when the culprit is involved.Also not all eye witness’ have very good memeory when it comes to facial recognition. Furthermore, there is the sort of identification which has to do with verbal recognition. Here, different set of audio recordings of different suspects are selected and then played for the witness to identify the culprit. This method is only used in critical situations where the witness did not see the suspect but heard the person speak. This could be difficult for the witness to identify especially when the tapes been played are similar.Sometimes too, the suspect is kept in a confined room with a recording device and is asked by the police to mention specific words suggested by the witness. These words are sometimes the ones the witness heard the suspect say at the time of the incident. In conclusion to the above procedures, the poli ce force can put in severe measures that could enhance or yield positive and effective results to make their work much easier and simpler. There are also instances whereby two or more procedures of identification are incorporated into one to help solve cases which are very delicate and special.

Friday, August 16, 2019

Character Traits of a Teenager

Someone asked me why does hate, anger, love, curiosity, admiration, etc. exist in the world. It was a very innocent yet important question that I would like to address. Seekers of the Spirit throughout time have noticed that the Divine Reality expresses in various ways, including Peace, Oneness, Wisdom, Knowledge, Creativity, Beauty, Goodness, Love, Delight, Power, Timelessness, and Infinity. These are also qualities that the Supreme seeks to manifest in the forms of creation. We humans are the means by which they take shape on earth. Interestingly, though the Intent of the Supreme was/is to spread these spiritual aspects throughout the cosmos, they initially took shape in their opposite form, as an inversion. For example, life first emerged in the universe as unconscious physical matter; and only after, emerged higher, more conscious forms. Thus, life, and indeed we humans have roots in unconsciousness mixed with the consciousness. And we have come to embody them in the form of both positive and negative character traits — expressing the physical, vital, and mental levels. An obvious question is why would a Divine Reality allow for both formations of darkness and light? Why not just manifest Its own, infinitely positive spiritual attributes? The answer is that it did so to enable the greatest variety, multiplicity, and possibility of experience. If there were only good traits, the diversity and depth of our life experiences would be limited. Thus, over time, a vast array of positive, neutral, and negative physical, vital, and mental traits came to be. For example, feelings like fear, anger, hatred, are negative expressions that originate in the vital plane of our being. It turns out that not only are these negative expressions inversions of their positive spiritual counterpart of Oneness, Power, Love, etc. , but inversions of our own positive human traits. For example, people who hate, secretly harbor love, but through circumstance inner and outer, have inverted to its darker side. A child might hate a parent because of their abuse, but secretly harbored intense love that reversed itself. In fact, the more intense the hate, the greater the possibility of love when the obstacles are overcome. In humanity's evolution we emerged from physical existence where our physical traits predominated, such as hunting and other survival skills, to the development of more complex vital feelings and relationships, such as trade, cooperation, and affinity toward marriage, to sophisticated traits of the mind, such as analyzing, synthesizing, calculating, rational thinking, etc. These are positive or neutral characteristics developed over the course of human evolution. And yet there are also negative qualities that developed, such as mental ignorance and falsehood. At the vital and physical levels there are far more and more virulent forms of negative character traits because as you go lower in human consciousness, the wanting characteristics tend to appear. Anger, hate, intense desire, lust, jealousy, etc. are negative vital traits; while domination, tendency to violence, etc. are examples of negative physical characteristics. And so we see how life evolved both a plethora of qualities in the human, both positive and negative, to enable the greatest variety of experience, from which we can evolve our nature and through that discovery experience delight.

Thursday, August 15, 2019

Biomedical Technology In Ethics and Religion

here are many misconceptions in biomedical genealogy, mostly caused by the many viewpoints and opinions concerning it. When formulating opinions and viewpoints, it Is crucial to be properly educated about that particular topic. The lack of knowledge and moral dispute may hinder clientele research. Although critics argue that it is unethical to manipulate DNA, with genetic manipulation, certain diseases can be eliminated, and cloning holds the ability to produce human organs viable for transplant.Critics argue that it Is unethical to manipulate DNA Some say it Is dangerous because there Is not much knowledge about it. However, genetic manipulation is not a new concept. Some may say that Hitler had this idea before most scientists. An Aryan race is what Hitler striver for. If only he knew that his idea of deciding what genes people receive would carry on even to this day. Scientists are discovering new ways to control what traits are passed through heredity. In the future parents may g et to decide what traits their children receive.This breakthrough in technology is very controversial. â€Å"Some critics continue to argue that it's unethical to manipulate the genetic makeup of human eggs even if here Specter of Human Cloning†). Many religious and moral leaders believe that manipulating DNA crosses a boundary that only God has the right to cross. Many also believe that scientists should not use human embryo in testing because it is wasting human life. Scientists are developing new tests that can determine whether or not a child has a birth defect or disability very early on In pregnancy.In this, parents can decide if they would like to keep their child or not. Religious and ethical people are outraged at such tests because they believe that human life should not be a choice. The problem is that researchers aren't allowed to use human embryo in such tests, Knish said, so Instead, they use animal embryo†(Peeler 6). The conflict with using animal embryo, Is that scientists do not get the same results as they would if they were to use human embryo. People expect exact results and breakthrough discoveries but they are not willing to pay the price.Genetic manipulation holds the chance that certain diseases can be eliminated. This Is one of the many benefits that come with genetic manipulation. Some say that scientists are finding new ways to control what traits get passed through heredity. If that is so, scientists can make the traits that carry heritable diseases vanish. If scientists can manipulate DNA to relinquish the formation of certain diseases, they will know what causes that disease. This advancement will not only prevent people from obtaining disease but will also eliminate It In people who already have It. We will see disease eliminated in the future, or we will witness the creation of new and 1 OFF unleashed†(Decolletage 75). Some believe that once technology goes so far it will be an unstoppable, dangerous force. Ma ny think that scientists manipulating DNA is imply too far. â€Å"Can we, however, ignore opportunities to improve human health†(Decolletage 51). What if no one in the world had cancer, down syndrome, or other disabilities and diseases? People would not oppose research so much if they knew what the outcome would be. People are afraid to take risks; they do not want to put their fate in someone else's hands.What if those hands cured illness and disease? In addition, new biomedical technology such as cloning holds the possibility of cloning human organs that are viable for transplant. Thousands of people each year die because of organ shortages. Cloning human organs can eliminate this epidemic. If organs can be specially made for each individual who needs one, organ transplant waiting lists can be eliminated. â€Å"†¦ An average of 18 people die each day waiting for transplants that can't take place because of the shortage of donated organs†(â€Å"The Need Is Real: Data†).These deaths can be prevented by cloning. However, many people believe that cloning is very unethical and goes against religion. This hinders the formation of cloning and holds back scientists from imperative research. The lack of support given by the people for cloning research impedes government and local ending and aid. The delay in funding and aid creates a rift in research. Many people support biomedical technology and cloning, but only to a certain extent. Most religious people are concerned about cloning because they believe that only God has the right to give and take life in any form.In reality, fear and the lack of knowledge inhibit many religious and ethical people from supporting the idea of cloning. â€Å"If we hope to direct the course of this powerful technology, we should strive to learn as much as we can about these molecular tools and then let scientists and corporations know our wishes. Only then can we truly expect to avoid the risks and enjoy the progress and the promises of our genetic future†(Decolletage 112). Advocates and antagonists both need to strive for further knowledge about this subject in order to tell scientists exactly what they want.How can scientists know how far to take their new technology, if no one has the correct knowledge to tell them where is too far? In conclusion, there are many opinions and viewpoints on the topic of biomedical technology. These can help but they can also hinder scientific research in many ways. One of which is the opinion of religious and ethical people. These people can bring up valid points and bring forth new thoughts and useful ideas about biomedical technology, but they can also let their personal views get in the way.Often times the opinions of religious and ethical people are blurred or disrupted by their personal views. This can lead to extremist views that believe all biomedical technology goes against religion and is unethical. Many people will align themselves with one ideal or theology without educating themselves and considering other viewpoints. In order for both sides of this debate to reach a compromise there must be an open forum of to only communication but also education between both parties.

Wednesday, August 14, 2019

Reflection Journal – Identity

reReflective Practice Journal Identity GNED 500 – 120 Brandon Tito – 300637791 Professor Selom Chapman-Nyaho Identity â€Å"The aspects of individuals and groups that include: language; ethnicity; gender; experience of migration/immigration; social class; political affiliations; family influences; age; sexual orientation; geographic origin; experience or absence of experience with discrimination† (GNED 500, p. 73). Our identity is the key that grants us a representation of who we are as citizens and what we stand for. Personal identification is what separates and differentiates us apart from other individuals in our world.Identity is strongly significant in our lives because the development of personal attributes and contributions is what makes us unique and superior in our own way. Our perspectives and points on how we view the world are also based on our personal identities and how we establish that image. A. How did it affect your thinking? While acquiring an adequate understanding about personal identities, it is important to build and create a â€Å"personal brand† for one’s self in which can be recognized and looked upon by others in a positive manner. B. Has it changed your perspective on a particular issue?How? Yes, having a clear understanding of our personal identities has changed my perspective on a particular issue. As emphasized on a familiar quote, â€Å"become a leader, not a follower†, this quote indicates a great representation of personal identities as well as personal branding. An individual should be superior to their own brand as well as justifying and claiming ownership of their identity and not mirroring a representation of someone else’s identity and brand. C. Has it raised any new questions? Most definitely, the term â€Å"identity† has had many questions raised in previous times.Many of these questions were raised from many different perspectives such as political, scientific, gen etic, academic, religious, and symbolic structures. All of which are social structures in our society. D. Will anything you learned change your actions? If so, how? Of course, with the knowledge acquired about the many different social structures and ideologies in our society, I am more observant and aware of misinterpretations that are presented in our society. It’s important to understand that social structures, ideologies, and the environment we surround ourselves in play a substantial role in shaping our personal identities and brands.Course Feedback Overall, my duration in partaking in the GNED-500 course has been a great academic experience for me. It’s a great opportunity to have a better understanding of the social structures and issues/concerns that shape our society today. With also being given the opportunity to establish a more superior personal brand towards myself†¦ Knowledge and understanding is power! I recommend this course to everybody, this is a great decision to enhance your personal knowledge on current and previous events that help build and sustain our society.